Publications MRic-Photonics


Le Gall-David S, Zenbaa N, Bouchard D, Lavault MT, Bonnaure-Mallet M, Jolivet-Gougeon A, Bousarghin L.  "Hypermutator Salmonella Heidelberg induces an early cell death in epithelial cells" Vet Microbiol. 2015 Oct 22;180(1-2):65-74.

Pacquelet A, Uhart P, Tassan JP, Michaux G." PAR-4 and anillin regulate myosin to coordinate spindle and furrow position during asymmetric division". 2015, J Cell Biol, 210, 1085-1099.

Gillard G, Shafaq-Zadah M, Nicolle O, Damaj, R, Pécréaux J, Michaux G. "Control of E-cadherin apical localisation and morphogenesis by a SOAP-1/AP-1/clathrin pathway in C. elegans epidermal cells."2015, Development, 142, 1684-94.

Nicolle O, Burel A, Griffiths G, Michaux G, Kolotuev I. "Adaptation of cryo-sectioning for immuno-EMlabeling of asymmetric samples: C. elegans case study."2015, Traffic, 16, 893-905.

Michaux G*, Massey-Harroche D, Nicolle O, Rabant M, Brousse N, Goulet O, Le Bivic A, Ruemmele FM."The localisation of the apical Par/Cdc42 polarity module is specifically affected in microvillus inclusion disease." 2015, Biol Cell, in press."

Caous, R., A. Pascal, P. Rome, L. Richard-Parpaillon, R. Karess, and R. Giet. 2015. "Spindle assembly checkpoint inactivation fails to suppress neuroblast tumour formation in aurA mutant Drosophila. Nat Commun. 6:8879.

Amin R, Mourcin F, Uhel F, Pangault C, Ruminy P, Dupré L, Guirriec M, Marchand T, Fest T, Lamy T, Tarte K. "DC-SIGN-expressing macrophages trigger activation of mannosylated IgM B-cell receptor in follicular lymphoma." Blood. 2015 Oct 15;126(16):1911-20

N. Loyer, I. Kolotuev, M. Pinot, R. Le Borgne. ‘Drosophila E-cadherin is required for the maintenance of ring canals anchoring to mechanically withstand tissue growth. Proc Natl Acad Sci U S A. 2015 Oct 13;112(41):12717-22


Paladino S, Lebreton S, Tivodar S, Formiggini F, Ossato G, Gratton E, Tramier M, Coppey-Moisan M, Zurzolo C. Golgi sorting regulates organization and activity of GPI proteins at apical membranes. Nat Chem Biol. (2014) 10:350-7.

Padilla-Parra S, Audugé N, Coppey-Moisan M, Tramier M. Quantitative study of protein-protein interactions in live cell by dual-color fluorescence correlation spectroscopy. Methods Mol Biol. (2014) 1076:683-98.

Khmelinskii A, Blaszczak E, Pantazopoulou M, Fischer B, Omnus DJ, Le Dez G, Brossard A, Gunnarsson A, Barry JD, Meurer M, Kirrmaier D, Boone C, Huber W, Rabut G, Ljungdahl PO, Knop M.  "Protein quality control at the inner nuclear membrane. Nature. 2014 Dec 18;516(7531):410-3.

Flouriot G, Huet G, Demay F, Pakdel F, Boujrad N, Michel D "-The actin/MKL1 signalling pathway influences cell growth and gene expression through large-scale chromatin reorganization and histone post-translational modifications. Biochem J. 2014 Jul 15;461(2):257-68.

Kerdivel G, Boudot A, Habauzit D, Percevault F, Demay F, Pakdel F, Flouriot G. Activation of the MKL1/actin signaling pathway induces hormonal escape in estrogen-responsive breast cancer cell lines. Mol Cell Endocrinol. 2014 Jun 5;390(1-2):34-44.

Gillard G, Shafaq-Zadah M, Nicolle O, Damaj R, Pécréaux J, Michaux G. Control of E-cadherin apical localisation and morphogenesis by a SOAP-1/AP-1/clathrin pathway in C. elegans epidermal cells. Development, in press

Abot A, Fontaine C, Buscato M, Solinhac R, Flouriot G, Fabre A, Drougard A, Rajan S, Laine M, Milon A, Muller I, Henrion D, Adlanmerini M, Valéra MC, Gompel A, Gerard C, Péqueux C, Mestdagt M, Raymond-Letron I, Knauf C, Ferriere F, Valet P, Gourdy P, Katzenellenbogen BS, Katzenellenbogen JA, Lenfant F, Greene GL, Foidart JM, Arnal JF. The uterine and vascular actions of estetrol delineate a distinctive profile of estrogen receptor α modulation, uncoupling nuclear and membrane activation. EMBO Mol Med. 2014 Sep 11;6(10):1328-46.

Dagher J, Dugay F, Rioux-Leclercq N, Verhoest G, Oger E, Bensalah K, Cabillic F, Jouan F, Kammerer-Jacquet SF, Fergelot P, Vigneau C, Arlot-Bonnemains Y, Belaud-Rotureau MA. Cytoplasmic PAR-3 protein expression is associated with adverse prognostic factors in clear cell renal cell carcinoma and independently impacts survival. Hum Pathol. 2014 Aug;45(8):1639-46.

Dianat N, Dubois-Pot-Schneider H, Steichen C, Desterke C, Leclerc P, Raveux A, Combettes L, Weber A, Corlu A*, Dubart-Kupperschmitt A*.Generation of functional cholangiocyte-like cells from human pluripotent stem cells and HepaRG cells. Hepatology. 2014 Aug;60(2):700-14.

SUMOylation of the ING1b tumor suppressor regulates gene transcription. Satpathy S, Guérillon C, Kim TS, Bigot N, Thakur S, Bonni S, Riabowol K, Pedeux R. Carcinogenesis. 2014 Oct;35(10):2214-23.

Lagarrigue M, Lavigne R, Tabet E, Genet V, Thomé JP, Rondel K, Guével B, Multigner L, Samson M and Charles Pineau C. Localization and in situ absolute quantification of chlordecone in the mouse liver by MALDI imaging. Analytical Chemistry.  2014 Jun 17;86(12):5775-83

Landemaine A, Rescan PY, Gabillard JC. Myomaker mediates fusion of fast myocytes in zebrafish embryos. Biochem Biophys Res Commun. 2014 Sep 5;451(4):480-4.

Dugay F, Le Goff X, Rioux-Leclerq N, Chesnel F, Jouan F, Henry C, Cabillic F, Verhoest G, Vigneau C, Arlot-Bonnemains Y, Belaud-Rotureau MA. (2014). Overexpression of the polarity protein PAR-3 in clear cell renal cell carcinoma is associated with poor prognosis. Int J Cancer. 134(9):2051-60.

Vignet C, Joassard L, Lyphout L, Guionnet T, Goubeau M, Le Menach K, Brion F, Kah O, Chung BC, Budzinski H, Bégout ML, Cousin X. Exposures of zebrafish through diet to three environmentally relevant mixtures of PAHs produce behavioral disruptions in unexposed F1 and F2 descendant.

Coumailleau P, Pellegrini E, Adrio F, Diotel N, Cano-Nicolau J, Nasri A, Vaillant C, Kah O. Aromatase, estrogen receptors and brain development in fish and amphibians Biochim Biophys Acta. 2015 Feb;1849(2):152-162.  Review.

Fetter E, Krauss M, Brion F, Kah O, Scholz S, Brack W. Effect-directed analysis for estrogenic compounds in a fluvial sediment sample using transgenic cyp19a1b-GFP zebrafish embryos. Aquat Toxicol. 2014 Sep;154:221-9.

Coumailleau P, Kah O.  Cyp19a1 (aromatase) expression in the Xenopus brain at different developmental stages. J Neuroendocrinol. 2014 Apr;26(4):226-36.

Kah O, Pellegrini E, Vaillant C, Brion F. (2014) Œstrogènes, xéno-œstrogènes et contrôle de la prolifération des cellules progénitrices neuronales chez le poisson zèbre :un modèle sentinelle pertinent en santé humaine? Correspondance en métabolisme, hormone, diabète et nutrition. MHDN XVIII(6): 140-143.

Kubiak, J.Z., Chartrain, I. and Tassan, J.P. (2014). Chapter 6: The Xenopus embryo as a model system to study asymmetric furrowing in vertebrate epithelial cells. "Xenopus Development". Wiley-Blackwell Editor. In press.

Chalmel F§, Com E§, Lavigne R, Hernio N, Teixeira-Gomes AP, Dacheux JL and Pineau C. An integrative omics strategy to assess the germ cell secretome and to decipher Sertoli-germ cell crosstalk in the mammalian. PloS ONE 2014, 9(8): e104418. PMID: 25111155. § These authors contributed equally to this work.



- Floriane Nicol-Benoit, Pascale le Goff and Denis Michel Drawing a Waddington landscape to capture dynamic epigenetics (2013) Biol. Cell. 105, 1-9.

- Denis Michel Kinetic approaches to lactose operon induction and bimodality (2013) J. Theor. Biol. 325, 62-75.

- Denis Michel and Philippe Ruelle Seven competing ways to recover the Michaelis-Menten equation reveal the alternative approaches to steady state modeling (2013) J. Math. Chem. 51, 2271–2284.

- Denis Michel Simply conceiving the Arrhenius law and absolute kinetic constants using the geometric distribution (2013) Physica A: Statistical Mechanics 392, 4258–4264.

- Denis Michel Life is a self-organizing machine driven by the informational cycle of Brillouin (2013) Orig. Life Evol. Biosph. 43, 137-150.

- Sylvain Lecomte, Léa Reverdy, Catherine Le Quément, Florent Le Masson, Axelle Amon, Pascale Le Goff, Denis Michel, Elisabeth Christians and Yves Le Dréan Unraveling complex interplay between Heat Shock Factor 1 and 2 splicing isoforms (2013) PLOS One. 8 (2), e56085

- Chartrain I., Le Page Y. , Hatte G., Körner R., Kubiak JZ. and Tassan J.P. (2013) Cell-cycle dependent localization of MELK and its new partner RACK1 in epithelial versus mesenchyme-like cells in Xenopus embryo. Biology Open 2, 1037-48.

- Riche, S., et al. (2013). "Evolutionary comparisons reveal a positional switch for spindle pole oscillations in Caenorhabditis embryos." J Cell Biol 201(5): 653-662.

- Le Vee M, Noel G, Jouan E, Stieger B, Fardel O. Polarized expression of drug transporters in differentiated human hepatoma HepaRG cells. Toxicol In Vitro. 2013 Sep;27(6):1979-86.

- Noel G, Le Vee M, Moreau A, Stieger B, Parmentier Y, Fardel O. Functional expression and regulation of drug transporters in monolayer- and sandwich-cultured mouse hepatocytes. Eur J Pharm Sci. 2013 Feb 6;49(1):39-50

- Noël G, Belghith M, Bélanger B, Leduc C, Daniel C. Direct alloreactivity is more susceptible to regulation by natural regulatory T cells than indirect alloreactivity. J Immunol. 2013 Apr 1;190(7):3764-71

- V. Meuric, B. Martin, H. Guyodo, A Rouillon, Z. Tamanai-Shacoori, F. Barloy-Hubler, M. Bonnaure-Mallet : Treponema denticola improves adhesive capacities of Porphyromonas gingivalis. Molecular Oral Microbiology (2013), vol 28, pp 40-53.

- Cadou A#, Couturier A#, Le Goff C, Xie L., Paulson J., Le Goff X. The Kin1 kinase and the calcineurin phosphatase cooperate to link actin ring assembly and septum synthesis in fission yeast. # Co-first authors. Cover Picture. Biol. Cell, 2013, 105(3):129-48.

- Ferriere F, Habauzit D, Pakdel F, Saligaut C, Flouriot G. (2013). Unliganded Estrogen Receptor Alpha Promotes PC12 Survival during Serum Starvation. PLoS One. 8(6):e69081.

- Kerdivel G, Flouriot G, Pakdel F. (2013). Modulation of estrogen receptor alpha activity and expression during breast cancer progression. Vitam Horm. 93:135-60.

- Détivaud L, Island ML, Jouanolle AM, Ropert M, Bardou-Jacquet E, Le Lan C, Mosser A, Leroyer P, Deugnier Y, David V, Brissot P, Loréal O. Ferroportin diseases: functional studies, a link between genetic and clinical phenotype. 2013. Hum Mutat. Nov;34(11):1529-36. doi: 10.1002

- Pérez MR, Pellegrini E, Cano-Nicolau J, Gueguen MM, Menouer-Le Guillou D, Merot Y, Vaillant C, Somoza GM, Kah O. Relationships between radial glial progenitors and 5-HT neurons in the paraventricular organ of adult zebrafish - potential effects of serotonin on adult neurogenesis.
Eur J Neurosci. 2013 Nov;38(9):3292-301

- Martin B, Chesnel F, Delcros JG, Jouan F, Couturier A, Dugay F, Le Goff X, Patard JJ, Fergelot P, Vigneau C, Rioux-Leclerq N, Arlot-Bonnemains Y. Identification of pVHL as a Novel Substrate for Aurora-A in Clear Cell Renal Cell Carcinoma (ccRCC). PLoS One. 2013 Jun 13;8(6):e67071. doi:10.1371/journal.pone.0067071. Print 2013. PubMed PMID: 23785518.

- Reboutier D, Troadec MB, Cremet JY, Chauvin L, Guen V, Salaun P, Prigent C. Aurora A is involved in central spindle assembly through phosphorylation of Ser 19 in P150Glued. J Cell Biol. 2013 Apr 1;201(1):65-79. doi:10.1083/jcb.201210060. Erratum in: J Cell Biol. 2013 Apr 29;201(3):487. PubMed PMID: 23547029; PubMed Central PMCID: PMC3613693.

- Dehapiot B, Carrière V, Carroll J, Halet G. Polarized Cdc42 activation promotes polar body protrusion and asymmetric division in mouse oocytes. Dev Biol. 2013 May 1;377(1):202-12. doi: 10.1016/j.ydbio.2013.01.029. Epub 2013 Feb 4. PubMed PMID: 23384564.

- Dehapiot B, Halet G. Ran GTPase promotes oocyte polarization by regulating ERM (Ezrin/Radixin/Moesin) inactivation. Cell Cycle. 2013 Jun 1;12(11):1672-8. doi:10.4161/cc.24901. Epub 2013 May 8. PubMed PMID: 23656777.

- Cotton M, Benhra N, Le Borgne R. Numb inhibits the recycling of Sanpodo in Drosophila sensory organ precursor. Curr Biol. 2013 Apr 8;23(7):581-7. doi:10.1016/j.cub.2013.02.020. Epub 2013 Mar 21. PubMed PMID: 23523246.

- Founounou N, Loyer N, Le Borgne R. Septins regulate the contractility of the actomyosin ring to enable adherens junction remodeling during cytokinesis of epithelial cells. Dev Cell. 2013 Feb 11;24(3):242-55. doi: 10.1016/j.devcel.2013.01.008. PubMed PMID: 23410939.

- Jaglarz M, Bazile F, laskowska K, polanski Z, chesnel F, orsuk E, kloc M, kubiak JZ. Association of TCTP with centrosome and microtubules. Biochem. Res. Int., 2012, ID 541906.

- Aymeric Leray, Sergi Padilla-Parra, Julien Roul, Laurent Héliot, Marc Tramier. 827Spatio-Temporal Quantification of FRET in Living Cells by Fast Time-Domain FLIM: A Comparative Study of Non-Fitting Methods. PLoS One. 2013 Jul 18;8(7):e69335. doi: 10.1371/journal.pone.0069335. Print 2013



- Padilla-Parra S, Tramier M. FRET microscopy in the living cell: Different approaches, strengths and weaknesses. BioEssays (2012) 34:369-76.

- Jourdan N, Jobart-Malfait A, Dos Reis G, Quignon F, Piolot T, Klein C, Tramier M, Coppey M, Marechal V. Live-cell imaging reveals multiple interactions between Epstein-Barr Nuclear Antigen 1 (EBNA-1) and cellular chromatin during interphase and mitosis. J Virol (2012) 86:5314-29.

- O. ROSTAN, F. ROBERT-GANGNEUX, M. LAMBERT, M. SAMSON and J. P. GANGNEUX. Human hepatic stellate cells in primary culture are safe targets for Leishmania donovani. Parasitology, 140, pp 471-481. doi:10.1017/S0031182012001965.

- Yoann Rannou, Patrick Salaun, Christelle Benaud, Jabbar Khan, Stéphanie Dutertre, Régis Giet and Claude Prigent. MNK1 kinase activity is required for abscission June 15. 2012 J Cell Sci 125, 2844-2852

- Frémin, C., Ezan, F., Guegan, J.-P., Gailhouste, L., Trotard, M., Le Seyec, J., Rageul, J., Theret, N., Langouët, S. and Baffet, G. (2012), The complexity of ERK1 and ERK2 MAPKs in multiple hepatocyte fate responses. J. Cell. Physiol., 227: 59–69. doi: 10.1002/jcp.22742

- Reboutier D, Troadec MB, Cremet JY, Fukasawa K and Prigent C. Nucleophosmin/B23 activates Aurora-A at the centrosome through phosphorylation of Serine 89. J Cell Biol. 197(1):19-26

- Le bras S, rondanino C, kriegel-taki G, dussert A, le borgne R. Genetic identification of intracellular trafficking regulators involved in notch dependent binary cell fate acquisition following asymmetric cell division.J. Cell Sci., 2012, 125(Pt20):4886-901.

- Shafaq-zadah M, brocard L, solari F, michaux G. AP-1 is required for the maintenance of apico-basal polarity in the C. elegans intestine.Development, 2012, 139(11):2061-2070.

- Kloc M, Tejpal N, Sidhu J, Ganachari M, Flores-Villanueva P, Jennings NB, Sood AK, Kubiak JZ, Ghobrial RM. Inverse relationship between TCTP/RhoA and p53 /cyclin A/actin expression in ovarian cancer cells. Folia Histochem Cytobiol. 2012 Oct 8;50(3):358-67. doi: 10.5603/19745. PubMed PMID: 23042265.



- MM Delage; S Dutertre; R Le Guevel; L Frolova; N. Berkova. Monoclonal antibodies against human translation termination factor eRF3 and their utilisation for subcellular localisation of eRF3. Journal of Biochemistry 2011; doi: 10.1093/jb/mvr035

- J Khan; F Ezan; JY Crémet; A Fautrel; D Gilot; M Lambert; C Benaud; MB Troadec; C Prigent. Overexpression of active aurora-C kinase in cell transformation and tumour formation. PLoS One 2011;6(10):e26512. Epub 2011 Oct 27.

- Padilla-Parra S, Audugé N, Coppey-Moisan M, Tramier M. Dual-color fluorescence lifetime correlation spectroscopy to quantify protein-protein interactions in live cell. Microsc Res Tech (2011) 74:788-93.

- Padilla-Parra S, Audugé N, Coppey-Moisan M, Tramier M. Non fitting based FRET–FLIM analysis approaches applied to quantify protein–protein interactions in live cells. Biophys Rev (2011) 3:63–70.

- J. Rageul; C. Frëmin; F. Ezan; G. Baffet; S. Langouët. The knock-down of ERCC1 but not of XPF causes multinucleation. DNA Repair 10 (2011) 978-990.

- Masse J, Piquet-Pellorce C, Viet J, Guerrier D, Pellerin I, Deschamps S. zfpip/zfp462 is involved in P19 cell pluripotency and in their neuronal fate. Exp. Cell Res., 2011, 317(13):1922-1934.

- Diotel N, Servili A, Gueguen MM, Mironov S, Pellegrini E, Vaillant C, Zhu Y, Kah O, Anglade I. Nuclear progesterone receptors are up-regulated by estrogens in neurons and radial glial progenitors in the brain of zebrafish. PLoS One. 2011;6(11):e28375. Epub 2011 Nov 30.

- Diotel N, Do Rego JL, Anglade I, Vaillant C, Pellegrini E, Vaudry H, Kah O. (2011) The brain of teleost fish, a source, and a target of sexual steroids. Front Neurosci. 2011;5:137

- Servili A, Herrera-Pérez P, Kah O, Muñoz-Cueto JA (2011) The retina is a target for GnRH-3 system in the European sea bass, Dicentrarchus labrax. Gen Comp Endocrinol. 2011 Nov 19. [Epub ahead of print]

- Le Page Y, Vosges M, Servili A, Brion F, Kah O (2011) Neuroendocrine effects of endocrine disruptors in teleost fish. J Toxicol Environ Health B Crit Rev. 2011;14(5-7):370-86.

- Trudeau VL, Kah O, Bourguignon JP (2011) Neuroendocrine disruption: the emerging concept. J Toxicol Environ Health B Crit Rev. 14(5-7):267-9

- Diotel N, Do Rego JL, Anglade I, Vaillant C, Pellegrini E, Gueguen MM, Mironov S, Vaudry H, Kah O (2011) Activity and expression of steroidogenic enzymes in the brain of adult zebrafish. Eur J Neurosci. 34(1):45-56.

- Canosa LF, Lopez GC, Scharrig E, Lesaux-Farmer K, Somoza GM, Kah O, Trudeau VL (2011) Forebrain mapping of secretoneurin-like immunoreactivity and its colocalization with isotocin in the preoptic nucleus and pituitary gland of goldfish. J Comp Neurol (18):3748-65.

- Vosges M, Kah O, Hinfray N, Chadili E, Le Page Y, Combarnous Y, Porcher JM, Brion F. 17α- Ethinylestradiol and nonylphenol affect the development of forebrain GnRH neurons through an estrogen receptors-dependent pathway. (2011) Reprod Toxicol. 2011 [Epub ahead of print]

- Servili A, Le Page Y, Leprince J, Caraty A, Escobar S, Parhar IS, Seong JY, Vaudry H, Kah O (2011) Organization of two independent kisspeptin systems derived from evolutionary-ancient kiss genes in the brain of zebrafish. Endocrinology 152(4):1527-40

- Benhra, N., Lallet, L., Cotton, M., Le Bras, S., Dussert, A., and Le Borgne, R. (2011). AP-1 controls the trafficking of Notch and Sanpodo toward E-Cadherin junctions in sensory organ precursors. Current Biology 21, 87-95.

- Burgess J, Jauregui M, Tan J, Rollins J, Lallet S, Leventis PA, Boulianne GL, Chang HC, Le Borgne R, Krämer H, Brill JA. (2011) AP-1 and clathrin are essential for secretory granule biogenesis in Drosophila. Mol Biol Cell. 2011 Jun 15;22(12):2094-105.

- Le Page, Y., Chartrain, I., Badouel, C. and Tassan, J.P. (2011). Function for xMELK in cell division reveals a transition in the mode of cytokinesis during Xenopus development’ by et al. Journal of Cell Science 124, 958-68.

- Franck N, Montembault E, Rome P, Pascal A, Cremet Jy, Giet R. Cdk11p58 Is Required For centriole duplication and Plk4 recruitment to mitotic centrosomes. PLoS ONE, 2011, 6(1):e14600.

- Bardou-Jacquet E, Island ML, Jouanolle AM, Détivaud L, Fatih N, Ropert M, Brissot E, Mosser A, Maisonneuve H, Brissot P, Loréal O. A novel N491S mutation in the human SLC11A2 gene impairs protein trafficking and in association with the G212V mutation leads to microcytic anemia and liver iron overload. Blood Cells Mol Dis. 2011 Dec 15;47(4):243-8.